Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2949-51. doi: 10.1073/pnas.96.6.2949.

Abstract

The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Chromosome Inversion*
  • Chromosomes, Human, Pair 14*
  • DNA-Binding Proteins / genetics*
  • Humans
  • Leukemia, T-Cell / genetics*
  • Molecular Sequence Data
  • Oncogene Proteins*
  • Oncogenes*
  • Proto-Oncogene Proteins*
  • Sequence Alignment
  • Transcription Factors / genetics*
  • Translocation, Genetic*

Substances

  • DNA-Binding Proteins
  • Oncogene Proteins
  • Proto-Oncogene Proteins
  • TCL1A protein, human
  • TCL1B protein, human
  • Transcription Factors

Associated data

  • GENBANK/AF110465
  • GENBANK/AF110466
  • GENBANK/AF110467