Abstract
In the form of vitamin B12, cobalt plays a number of crucial roles in many biological functions. However, recent studies have provided information on the biochemistry and bioinorganic chemistry of several proteins containing cobalt in a form other than that in the corrin ring of vitamin B12. To date, eight noncorrin-cobalt-containing enzymes (methionine aminopeptidase, prolidase, nitrile hydratase, glucose isomerase, methylmalonyl-CoA carboxytransferase, aldehyde decarbonylase, lysine-2,3-aminomutase, and bromoperoxidase) have been isolated and characterized. A cobalt transporter is involved in the metallocenter biosynthesis of the host cobalt-containing enzyme, nitrile hydratase. Understanding the differences between cobalt and nickel transporters might lead to drug development for gastritis and peptic ulceration.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aldose-Ketose Isomerases / chemistry
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Amino Acid Sequence
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Aminopeptidases / chemistry
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Animals
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Bacterial Proteins*
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Binding Sites / genetics
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Cation Transport Proteins*
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Cobalt / chemistry*
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Dipeptidases / chemistry
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Escherichia coli / enzymology
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Humans
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Hydro-Lyases / chemistry
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Hydro-Lyases / genetics
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Methionyl Aminopeptidases
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Models, Molecular
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Molecular Sequence Data
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Protein Structure, Secondary
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Proteins / chemistry*
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Sequence Homology, Amino Acid
Substances
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Bacterial Proteins
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Carrier Proteins
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Cation Transport Proteins
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Membrane Proteins
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NhlF protein, Rhodococcus rhodochrous
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Proteins
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Cobalt
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Aminopeptidases
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Methionyl Aminopeptidases
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Dipeptidases
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proline dipeptidase
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Hydro-Lyases
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nitrile hydratase
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Aldose-Ketose Isomerases
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xylose isomerase