Abstract
Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Apoptosis / immunology*
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Clonal Anergy / immunology*
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Humans
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Lupus Erythematosus, Systemic / genetics
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Lupus Erythematosus, Systemic / immunology*
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Lymphocytes / immunology*
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Receptors, Antigen, B-Cell / deficiency
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Receptors, Antigen, B-Cell / immunology*
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Receptors, Antigen, T-Cell / deficiency
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction / immunology*
Substances
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Receptors, Antigen, B-Cell
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Receptors, Antigen, T-Cell