Expression of glutamate transporters in the adult bovine corpus callosum

Brain Res Mol Brain Res. 1999 Apr 20;67(2):296-302. doi: 10.1016/s0169-328x(99)00072-8.

Abstract

The presence and distribution of the glutamate transporters, EAAC1, GLAST and GLT-1, were examined in the adult bovine corpus callosum by means of Western blotting and immunohistochemistry. We found GLAST to be expressed in oligodendrocytes and in some astrocytes. GLT-1 was located throughout the processes of fibrous astrocytes. In addition, EAAC1 was present in a small population of cells that are probably adult oligodendrocyte progenitor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / analysis
  • ATP-Binding Cassette Transporters / analysis
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism
  • Age Factors
  • Amino Acid Transport System X-AG
  • Animals
  • Astrocytes / chemistry
  • Astrocytes / metabolism
  • Blotting, Western
  • Carrier Proteins / analysis
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Cattle
  • Cell Size / physiology
  • Corpus Callosum / chemistry*
  • Corpus Callosum / cytology
  • Corpus Callosum / metabolism
  • Fluorescent Antibody Technique
  • Gene Expression / physiology
  • Glial Fibrillary Acidic Protein / analysis
  • Glutamate Plasma Membrane Transport Proteins
  • Glutamic Acid / metabolism*
  • Homeostasis / genetics
  • Intermediate Filament Proteins / analysis
  • Nerve Tissue Proteins*
  • Nestin
  • Neurons / chemistry
  • Neurons / cytology
  • Oligodendroglia / chemistry
  • Oligodendroglia / enzymology
  • Stem Cells / chemistry
  • Stem Cells / enzymology
  • Symporters*

Substances

  • ATP-Binding Cassette Transporters
  • Amino Acid Transport System X-AG
  • Carrier Proteins
  • Glial Fibrillary Acidic Protein
  • Glutamate Plasma Membrane Transport Proteins
  • Intermediate Filament Proteins
  • Nerve Tissue Proteins
  • Nestin
  • Symporters
  • Glutamic Acid
  • 2',3'-Cyclic-Nucleotide Phosphodiesterases