Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

S Kurihara; T Tsumuraya; I Fujii

doi:10.1016/s0960-894x(99)00154-7

Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

Bioorg Med Chem Lett. 1999 Apr 19;9(8):1179-84. doi: 10.1016/s0960-894x(99)00154-7.

Authors

S Kurihara¹, T Tsumuraya, I Fujii

Affiliation

¹ Biomolecular Engineering Research Institute, Suita, Osaka, Japan.

PMID: 10328309
DOI: 10.1016/s0960-894x(99)00154-7

Abstract

Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.

MeSH terms

Amino Acids, Diamino / chemical synthesis*
Amino Acids, Diamino / chemistry*
Amino Acids, Diamino / pharmacokinetics*
Drug Design*
HIV Protease Inhibitors / chemical synthesis*
HIV Protease Inhibitors / chemistry*
HIV Protease Inhibitors / pharmacokinetics*
Models, Chemical

Substances

Amino Acids, Diamino
HIV Protease Inhibitors