Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism

Diabetes. 1999 Feb;48(2):423-5. doi: 10.2337/diabetes.48.2.423.

Authors

M Lehto¹, P O Bitzén, B Isomaa, C Wipemo, Y Wessman, C Forsblom, T Tuomi, M R Taskinen, L Groop

Affiliation

¹ Department of Endocrinology, Dalby Primary Health Center, University of Lund, Sweden. markku.lehto@endo.mas.lu.se

PMID: 10334325
DOI: 10.2337/diabetes.48.2.423

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
DNA-Binding Proteins*
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / genetics*
Diabetes Mellitus, Type 2 / metabolism*
Female
Hepatocyte Nuclear Factor 4
Humans
Insulin / deficiency
Insulin / metabolism*
Insulin Secretion
Male
Middle Aged
Mutation / genetics
Mutation / physiology*
Phosphoproteins / genetics*
Transcription Factors / genetics*
Triglycerides / blood*

Substances

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
DNA-Binding Proteins
HNF4A protein, human
Hepatocyte Nuclear Factor 4
Insulin
MLX protein, human
Phosphoproteins
Transcription Factors
Triglycerides