Abstract
Cyclic ADP-ribose (cADPR) was discovered as a potent Ca2+-mobilising natural compound in sea urchin eggs. Recently, cADPR was reported to stimulate Ca2+ signalling in several higher eukaryotic cell systems (e.g., smooth and cardiac muscle cells, neuronal cells, adrenal chromaffin cells, macrophages, pancreatic acinar cells and T-lymphocytes). The following aspects of the role of cADPR as a Ca2+-mobilising second messenger are reviewed: coupling of metabolism of cADPR to stimulation of receptors in the plasma membrane, properties and pharmacology of Ca2+ release by cADPR and the involvement of cADPR in Ca2+ entry.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Adenosine Diphosphate Ribose / analogs & derivatives*
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Adenosine Diphosphate Ribose / metabolism
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Animals
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Antigens, CD*
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Antigens, Differentiation / metabolism
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Calcium / metabolism*
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Calcium Signaling
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Cyclic ADP-Ribose
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Humans
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Membrane Glycoproteins
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NAD+ Nucleosidase / metabolism
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Receptors, Cell Surface / metabolism
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Second Messenger Systems*
Substances
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Antigens, CD
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Antigens, Differentiation
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Membrane Glycoproteins
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Receptors, Cell Surface
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Cyclic ADP-Ribose
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Adenosine Diphosphate Ribose
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ADP-ribosyl Cyclase
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CD38 protein, human
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NAD+ Nucleosidase
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ADP-ribosyl Cyclase 1
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Calcium