Inhibition of aromatase activity by flavonoids

Arch Pharm Res. 1999 Jun;22(3):309-12. doi: 10.1007/BF02976369.

Abstract

In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aromatase / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Evaluation
  • Female
  • Flavonoids / pharmacology*
  • Humans
  • Microsomes / enzymology*
  • Placenta / enzymology*
  • Pregnancy
  • Time Factors

Substances

  • Flavonoids
  • Aromatase