Abstract
We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Binding Sites
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Brain Neoplasms / genetics
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Brain Neoplasms / pathology
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Chromosome Mapping
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Chromosomes, Human, Pair 15 / genetics*
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DNA, Complementary / genetics
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Drosophila Proteins*
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Drosophila melanogaster / genetics
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Expressed Sequence Tags
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Gene Library
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Glioblastoma / genetics
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Glioblastoma / pathology
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HeLa Cells
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Homeodomain Proteins / genetics
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Humans
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Insect Proteins / genetics
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Molecular Sequence Data
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Molecular Weight
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Multigene Family*
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Oncogenes*
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Phosphorylation
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Protein Binding
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Protein Processing, Post-Translational
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Recombinant Fusion Proteins / metabolism
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Retinoblastoma Protein / metabolism*
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Sequence Alignment
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Sequence Homology, Amino Acid
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Trans-Activators / chemistry
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Trans-Activators / genetics
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Transcription Factors
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Transfection
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Tumor Cells, Cultured
Substances
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ARID3A protein, human
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ARID3B protein, human
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DNA, Complementary
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DNA-Binding Proteins
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Drosophila Proteins
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Homeodomain Proteins
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Insect Proteins
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Neoplasm Proteins
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Nuclear Proteins
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Recombinant Fusion Proteins
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Retinoblastoma Protein
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Retn protein, Drosophila
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Trans-Activators
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Transcription Factors