Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product

Cancer Res. 1999 Aug 1;59(15):3741-7.

Abstract

We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15 / genetics*
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics
  • Expressed Sequence Tags
  • Gene Library
  • Glioblastoma / genetics
  • Glioblastoma / pathology
  • HeLa Cells
  • Homeodomain Proteins / genetics
  • Humans
  • Insect Proteins / genetics
  • Molecular Sequence Data
  • Molecular Weight
  • Multigene Family*
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Oncogenes*
  • Phosphorylation
  • Protein Binding
  • Protein Processing, Post-Translational
  • Recombinant Fusion Proteins / metabolism
  • Retinoblastoma Protein / metabolism*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Trans-Activators / chemistry
  • Trans-Activators / genetics
  • Transcription Factors
  • Transfection
  • Tumor Cells, Cultured

Substances

  • ARID3A protein, human
  • ARID3B protein, human
  • DNA, Complementary
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Homeodomain Proteins
  • Insect Proteins
  • Neoplasm Proteins
  • Nuclear Proteins
  • Recombinant Fusion Proteins
  • Retinoblastoma Protein
  • Retn protein, Drosophila
  • Trans-Activators
  • Transcription Factors