Abstract
Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis. It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution.
MeSH terms
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Amino Acid Sequence
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Animals
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Biological Evolution
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DNA-Binding Proteins / genetics*
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Eye / growth & development*
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Eye Proteins / genetics*
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Homeodomain Proteins*
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Humans
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Molecular Sequence Data
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PAX6 Transcription Factor
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Paired Box Transcription Factors
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Repressor Proteins
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Sequence Homology, Amino Acid
Substances
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DNA-Binding Proteins
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Eye Proteins
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Homeodomain Proteins
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PAX6 Transcription Factor
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PAX6 protein, human
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Paired Box Transcription Factors
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Repressor Proteins