Abstract
Human neurochondrins have been cloned from a brain cDNA library. The human neurochondrin-1 and -2 predict leucine-rich (15.8 and 15.9%) proteins of 729 and 712 amino acid residues, with molecular weights of 78.9 and 77.2 kDa, respectively. The deduced amino acid sequence indicates 98% identity among human, mouse and rat species. Northern analysis indicates that about 4 kb human neurochondrin mRNAs are abundant in the fetal and the adult brain.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Blotting, Northern
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Brain / metabolism*
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Cloning, Molecular
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DNA, Complementary / chemistry
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DNA, Complementary / isolation & purification
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Gene Expression
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Gene Library
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Humans
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / genetics*
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Polymerase Chain Reaction
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RNA, Messenger / analysis
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Sequence Alignment
Substances
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DNA, Complementary
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NCDN protein, human
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Nerve Tissue Proteins
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RNA, Messenger
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neurochondrin-2
Associated data
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GENBANK/AB018739
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GENBANK/AB018740