Abstract
A newly discovered family of small proteins in the yeast mitochondrial intermembrane space mediates import of hydrophobic proteins from the cytoplasm into the inner membrane. Loss of one of these chaperone-like proteins from human mitochondria results in a disease that causes deafness, muscle weakness and blindness.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Biological Transport
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Humans
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Intracellular Membranes / metabolism*
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Membrane Proteins / metabolism*
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Mitochondria / metabolism*
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Mitochondria / pathology
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Molecular Chaperones / chemistry
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Molecular Chaperones / genetics
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Molecular Chaperones / metabolism*
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Molecular Sequence Data
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Syndrome
Substances
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Membrane Proteins
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Molecular Chaperones