Multiple sclerosis: side effects of interferon beta therapy and their management

Neurology. 1999 Nov 10;53(8):1622-7. doi: 10.1212/wnl.53.8.1622.

Abstract

Article abstract-Interferon beta (IFNbeta) reduces the relapse rate, disease activity as measured by serial MRI scanning, and disease progression of MS. Therapy with IFNbeta may be associated with a number of adverse reactions. Relatively frequent side effects include flu-like symptoms, transient laboratory abnormalities, menstrual disorders, and increased spasticity. Dermal injection site reactions occur after subcutaneous application of IFNbeta-1b and IFNbeta-1a. Possible side effects of IFNbeta include various autoimmune reactions, capillary leak syndrome, anaphylactic shock, thrombotic-thrombocytopenic purpura, insomnia, headache, alopecia, and depression. We discuss the mechanisms and management of the different side effects of IFNbeta.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Affect / drug effects
  • Female
  • Humans
  • Influenza, Human / chemically induced
  • Interferon-beta / adverse effects*
  • Lactation / drug effects
  • Menstruation Disturbances / chemically induced
  • Multiple Sclerosis / drug therapy*
  • Muscle Spasticity / chemically induced
  • Pregnancy / drug effects

Substances

  • Interferon-beta