Low oestrogen receptor alpha expression in normal breast tissue underlies low breast cancer incidence in Japan

Lancet. 1999 Nov 20;354(9192):1787-8. doi: 10.1016/s0140-6736(99)04936-3.

Abstract

Among white Australians without breast cancer, the median of the percentage of oestrogen receptor alpha positive cells was 12% for women younger than 50 years and 17% for those 50 years or older; among Japanese women who had no breast cancer and are generally at low risk for this disease, the corresponding values were both significantly lower and around 9%.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Adult
  • Aged
  • Australia / epidemiology
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / ethnology
  • Breast Neoplasms / metabolism*
  • Estrogen Receptor alpha
  • Female
  • Humans
  • Incidence
  • Japan / epidemiology
  • Middle Aged
  • Receptors, Estrogen / metabolism*

Substances

  • Estrogen Receptor alpha
  • Receptors, Estrogen