Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons

FEBS Lett. 1999 Nov 26;462(1-2):117-20. doi: 10.1016/s0014-5793(99)01519-7.

Abstract

Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Electrophysiology
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / metabolism*
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Molecular Sequence Data
  • NAV1.8 Voltage-Gated Sodium Channel
  • NAV1.9 Voltage-Gated Sodium Channel
  • Neurons / metabolism*
  • Neuropeptides / drug effects
  • Neuropeptides / genetics
  • Neuropeptides / metabolism*
  • Sodium Channels / chemistry
  • Sodium Channels / drug effects
  • Sodium Channels / genetics
  • Sodium Channels / metabolism*
  • Sodium Channels / physiology
  • Tetrodotoxin / toxicity

Substances

  • NAV1.8 Voltage-Gated Sodium Channel
  • NAV1.9 Voltage-Gated Sodium Channel
  • Neuropeptides
  • SCN10A protein, human
  • SCN11A protein, human
  • Scn10a protein, mouse
  • Scn10a protein, rat
  • Scn11a protein, mouse
  • Sodium Channels
  • Tetrodotoxin

Associated data

  • GENBANK/AF188679