Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

J Med Chem. 1999 Dec 2;42(24):4928-31. doi: 10.1021/jm9904598.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Bacterial Outer Membrane Proteins / antagonists & inhibitors*
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / genetics
  • Carrier Proteins / antagonists & inhibitors*
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Dipeptides / chemical synthesis*
  • Dipeptides / pharmacology
  • Drug Resistance, Microbial
  • Drug Stability
  • Drug Synergism
  • Endopeptidases / metabolism
  • Gene Expression
  • Levofloxacin*
  • Membrane Transport Proteins*
  • Molecular Structure
  • Ofloxacin / pharmacology*
  • Ornithine / chemistry
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / metabolism
  • Structure-Activity Relationship

Substances

  • Anti-Infective Agents
  • Bacterial Outer Membrane Proteins
  • Carrier Proteins
  • Dipeptides
  • Membrane Transport Proteins
  • MexA protein, Pseudomonas aeruginosa
  • MexB protein, Pseudomonas aeruginosa
  • OprM protein, Pseudomonas aeruginosa
  • phenylalanyl-N(alpha)-methylornithine 2-naphthyl amide
  • Levofloxacin
  • Ofloxacin
  • Ornithine
  • Endopeptidases