Testosterone 5alpha-reductase inhibitor bisnaphthoquinone derivative from Impatiens balsamina

Phytother Res. 2000 Feb;14(1):54-6. doi: 10.1002/(sici)1099-1573(200002)14:1<54::aid-ptr540>3.0.co;2-q.

Abstract

The 35% EtOH extract of aerial parts of Impatiens balsamina L. has been investigated for activity against testosterone 5alpha-reductase. Activity-guided fractionation led to the identification of the bisnaphthquione derivative named impatienol (1), 3-hydroxy-2-¿[3-hydroxy-1,4-dioxo (2-naphthyl)] ethyl¿ naphthalene-1, 4-dione, which exhibited significant testosterone 5alpha-reductase inhibitory activity. This 5alpha-reductase inhibitory compound has been previously synthesized, but this is the first report of its isolation from a natural source.

MeSH terms

  • 5-alpha Reductase Inhibitors*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Naphthoquinones / pharmacology*
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*

Substances

  • 5-alpha Reductase Inhibitors
  • Enzyme Inhibitors
  • Naphthoquinones
  • Plant Extracts