Regulation of protein phosphatase-1

J B Aggen; A C Nairn; R Chamberlin

doi:10.1016/s1074-5521(00)00069-7

Regulation of protein phosphatase-1

Chem Biol. 2000 Jan;7(1):R13-23. doi: 10.1016/s1074-5521(00)00069-7.

Authors

J B Aggen¹, A C Nairn, R Chamberlin

Affiliation

¹ Department of Chemistry, University of California, Advanced Medicine, Inc., Irvine, South San Francisco, CA 92697, USA.

PMID: 10662690
DOI: 10.1016/s1074-5521(00)00069-7

Abstract

Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Gene Expression Regulation, Enzymologic / genetics*
Humans
Molecular Sequence Data
Phosphoprotein Phosphatases / biosynthesis*
Phosphoprotein Phosphatases / genetics*
Protein Phosphatase 1
Regulatory Sequences, Nucleic Acid / genetics

Substances

Phosphoprotein Phosphatases
Protein Phosphatase 1