Abstract
The vertebrate integrins provide a paradigm for cell surface proteins involved in adhesion and morphogenesis. However, homologs of integrins have been found in more primitive organisms. This review will discuss the evidence for surface proteins in Candida albicans and Candida tropicalis that contain motifs reminiscent of integrins and will analyze the contributions of one of these proteins, Int1p, to adhesion, morphogenesis, and virulence. Other microorganisms thought to express integrin-like proteins will also be addressed.
Copyright 1999 Academic Press.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Candida / chemistry
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Candida / genetics
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Candida / pathogenicity
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Candida / physiology*
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Candida albicans / genetics
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Candida albicans / metabolism
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Cell Adhesion Molecules* / chemistry
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Cell Adhesion Molecules* / genetics
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Cell Adhesion Molecules* / physiology
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Fungal Proteins* / chemistry
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Fungal Proteins* / genetics
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Fungal Proteins* / physiology
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Genes, Fungal
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Integrins* / chemistry
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Integrins* / genetics
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Integrins* / physiology
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Molecular Sequence Data
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Virulence
Substances
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Cell Adhesion Molecules
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Fungal Proteins
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Integrins
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alphaINT1 protein, Candida albicans