Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact

S Chansakaow; T Ishikawa; H Seki; K Sekine (née Yoshizawa); M Okada; C Chaichantipyuth

doi:10.1021/np990547v

Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact

J Nat Prod. 2000 Feb;63(2):173-5. doi: 10.1021/np990547v.

Authors

S Chansakaow¹, T Ishikawa, H Seki, K Sekine (née Yoshizawa), M Okada, C Chaichantipyuth

Affiliation

¹ Faculty of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.

PMID: 10691701
DOI: 10.1021/np990547v

Abstract

Miroestrol (1) has been isolated previously as an active principle from "Kwao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.

MeSH terms

Antineoplastic Agents, Phytogenic / analysis*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Coumarins
Drug Screening Assays, Antitumor
Estrogens, Non-Steroidal / analysis*
Estrogens, Non-Steroidal / isolation & purification
Estrogens, Non-Steroidal / pharmacology
Humans
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Steroids
Thailand
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Coumarins
Estrogens, Non-Steroidal
Steroids
deoxymiroestrol