Abstract
Over the past few years, the long-standing idea that covalent modification of chromatin can play a role in determining states of gene activity has been confirmed. Eukaryotic genes can be silenced by deacetylation of acetyl-lysine moieties in the N-terminal tails of histones. Recent work links histone deacetylases with an increasing number of repressors, suggesting that deacetylation might be a rather pervasive feature of transcriptional repression systems.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carrier Proteins / metabolism
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DNA-Binding Proteins / metabolism
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Gene Silencing*
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Histone Deacetylases / physiology*
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Humans
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Ikaros Transcription Factor
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Nuclear Proteins / metabolism
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Nuclear Receptor Co-Repressor 1
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Proto-Oncogene Proteins / metabolism
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Repressor Proteins / metabolism
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Saccharomyces cerevisiae Proteins*
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Smad3 Protein
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Trans-Activators / metabolism
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Transcription Factors / metabolism
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Tumor Suppressor Protein p53 / metabolism
Substances
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Carrier Proteins
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DNA-Binding Proteins
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IKZF1 protein, human
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IKZF3 protein, human
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NCOR1 protein, human
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Nuclear Proteins
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Nuclear Receptor Co-Repressor 1
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Proto-Oncogene Proteins
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Repressor Proteins
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SIN3 protein, S cerevisiae
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SMAD3 protein, human
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Saccharomyces cerevisiae Proteins
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Smad3 Protein
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Trans-Activators
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Transcription Factors
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Tumor Suppressor Protein p53
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SKI protein, human
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Ikaros Transcription Factor
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MTA2 protein, human
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Histone Deacetylases