Abstract
Receptor protein tyrosine phosphatases (RPTPs), are involved in axon outgrowth and guidance not only in the Drosophila visual system (Garrity et al., 1999. Neuron 22, 707-717) but also in the developing vertebrate retina (Ledig et al., 1999a. J. Cell Biol. 147, 375-388). We have cloned a variety of Xenopus RPTPs, including four RPTPs expressed in the developing visual system (LAR, PTP-delta, CRYP-alpha and PTP-rho). These four RPTPs are transcribed in the developing optic vesicle during differentiation and in overlapping but distinct patterns in the developing retina during retinal layer formation. LAR, PTP-delta, and CRYP-alpha are also expressed in retinal ganglion cells during axonogenesis and during axon guidance from the retina to the optic tectum.
MeSH terms
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Animals
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Axons / metabolism
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Embryo, Nonmammalian
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Gene Expression Regulation, Developmental
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Molecular Sequence Data
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Protein Tyrosine Phosphatases / genetics*
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Protein Tyrosine Phosphatases / metabolism
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Receptor Protein-Tyrosine Kinases / genetics*
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Receptor Protein-Tyrosine Kinases / metabolism
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Receptor-Like Protein Tyrosine Phosphatases
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Receptor-Like Protein Tyrosine Phosphatases, Class 2
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Retina / embryology
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Retina / physiology
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Vision, Ocular / physiology*
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Xenopus / embryology
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Xenopus / genetics*
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Xenopus Proteins*
Substances
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Xenopus Proteins
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Receptor Protein-Tyrosine Kinases
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CRYPalpha protein, Xenopus
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Protein Tyrosine Phosphatases
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Ptprd protein, Xenopus
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Receptor-Like Protein Tyrosine Phosphatases
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Receptor-Like Protein Tyrosine Phosphatases, Class 2
Associated data
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GENBANK/AF173857
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GENBANK/AF197944
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GENBANK/AF197945
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GENBANK/AF198450