Abstract
Many Gram-negative pathogens use a type III secretion machine to translocate protein toxins across the bacterial cell envelope. Pathogenic Yersinia spp. export at least 14 Yop proteins via a type III machine, which recognizes secretion substrates by signals encoded in yop mRNA or chaperones bound to unfolded Yop proteins. During infection, substrate recognition appears to be regulated in a manner that allows the Yersinia type III pathway to direct Yops to the bacterial envelope, the extracellular medium or into the cytosol of host cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism*
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Cells, Cultured
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Eukaryotic Cells / microbiology
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Gram-Negative Bacteria / metabolism*
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Gram-Negative Bacteria / pathogenicity
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Gram-Negative Bacterial Infections / microbiology
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Molecular Chaperones / genetics
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Molecular Chaperones / metabolism*
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Signal Transduction
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Yersinia / metabolism
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Yersinia / pathogenicity
Substances
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Bacterial Outer Membrane Proteins
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Molecular Chaperones