New approaches to cancer chemotherapy with methotrexate

N Engl J Med. 1975 Apr 17;292(16):846-51. doi: 10.1056/NEJM197504172921607.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Biological Transport
  • Bone Marrow / drug effects
  • Creatinine / blood
  • DNA, Neoplasm / biosynthesis
  • Doxorubicin / therapeutic use
  • Drug Therapy, Combination
  • Humans
  • Kidney / drug effects
  • Leucovorin / administration & dosage*
  • Leucovorin / therapeutic use
  • Leukemia L1210 / drug therapy
  • Lung Neoplasms / prevention & control
  • Methotrexate / administration & dosage*
  • Methotrexate / therapeutic use
  • Methotrexate / toxicity
  • Mice
  • Neoplasm Metastasis / prevention & control
  • Neoplasms / drug therapy*
  • Osteosarcoma / drug therapy
  • Purines / biosynthesis
  • Thymidine / therapeutic use
  • Thymine Nucleotides / biosynthesis

Substances

  • DNA, Neoplasm
  • Purines
  • Thymine Nucleotides
  • Doxorubicin
  • Creatinine
  • Leucovorin
  • Thymidine
  • Methotrexate