Abstract
Production of beta-lactamase by 15 strains of Haemophilus influenzae has been investigated. All the strains produce a constitutive beta-lactamase, which readily hydrolyses penicillin G, ampicillin, and cephaloridine. The beta-lactamase produced by these strains is indistinguishable from the type-IIIa enzyme commonly found in strains of Escherichia coli. The beta-lactamase gene has been transferred from the enzyme-producing strains of Haemophilus to strains of H. parainfluenzae and a strain of E. coli.
MeSH terms
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Amidohydrolases / biosynthesis*
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Ampicillin / metabolism
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Anti-Bacterial Agents / pharmacology
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Cephaloridine / metabolism
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Cephalosporinase / biosynthesis*
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Conjugation, Genetic
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Haemophilus influenzae / drug effects
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Haemophilus influenzae / enzymology*
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Hydrolysis
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Penicillin G / metabolism
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Penicillin Resistance*
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Penicillinase / biosynthesis*
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R Factors*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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beta-Lactams
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Ampicillin
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Amidohydrolases
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Cephalosporinase
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Penicillinase
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Cephaloridine
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Penicillin G