Abstract
We determined circulatory polymorphonuclear leukocytes (PMN) functions of superoxide anion production, adhesion and aggregation in 38 type 2 diabetic patients with and without diabetic triopathy. Tumor necrosis factor (TNF)-alpha-stimulated superoxide production and N-formyl-methionyl-leucyl-phenylalanine (FMLP)-stimulated aggregation in diabetic patients with triopathy were significantly greater than those in diabetics without triopathy. The more diabetic complications existed, the more TNF-alpha-stimulated superoxide was produced by PMN. These results suggest that the activated PMN contributes to a progression of diabetic triopathy in type 2 diabetic patients.
MeSH terms
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Cell Adhesion / physiology
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Cell Aggregation / physiology
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / metabolism
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Diabetes Mellitus, Type 2 / pathology*
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Diabetic Nephropathies / metabolism
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Diabetic Nephropathies / pathology*
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Diabetic Neuropathies / metabolism
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Diabetic Neuropathies / pathology*
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Diabetic Retinopathy / metabolism
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Diabetic Retinopathy / pathology*
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Female
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Glycated Hemoglobin / metabolism
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Granulocytes / drug effects
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Granulocytes / metabolism
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Humans
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Lipid Peroxides / blood
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Male
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Middle Aged
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Neutrophils / physiology*
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Oxygen Consumption / physiology
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Superoxides / metabolism
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Tumor Necrosis Factor-alpha / pharmacology
Substances
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Glycated Hemoglobin A
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Lipid Peroxides
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Tumor Necrosis Factor-alpha
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Superoxides