Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors

Nat Med. 2000 Jun;6(6):659-66. doi: 10.1038/76233.

Abstract

We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon alpha/beta receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / cytology*
  • Base Sequence
  • Bone Marrow / metabolism
  • Cell Line, Transformed
  • Cloning, Molecular
  • Cytokines / analysis
  • Cytokines / genetics
  • Cytokines / physiology*
  • DNA, Complementary
  • DNA-Binding Proteins / metabolism
  • Female
  • Gene Expression
  • Growth Inhibitors / genetics
  • Growth Inhibitors / metabolism
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Interferon Regulatory Factor-1
  • Interferon Type I / chemistry
  • Membrane Proteins
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Molecular Sequence Data
  • Phosphoproteins / metabolism
  • Receptor, Interferon alpha-beta
  • Receptors, Interferon / genetics
  • Receptors, Interferon / metabolism
  • Signal Transduction
  • Spleen / metabolism
  • Tumor Cells, Cultured

Substances

  • Cytokines
  • DNA, Complementary
  • DNA-Binding Proteins
  • Growth Inhibitors
  • IRF1 protein, human
  • Interferon Regulatory Factor-1
  • Interferon Type I
  • Irf1 protein, mouse
  • Membrane Proteins
  • Phosphoproteins
  • Receptors, Interferon
  • limitin
  • Receptor, Interferon alpha-beta

Associated data

  • GENBANK/AB024521