Abstract
Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Colonic Neoplasms
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Ethers, Cyclic / chemistry*
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Ethers, Cyclic / pharmacology*
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Humans
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Leukemia
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Macrolides
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Mice
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Ethers, Cyclic
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Macrolides
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halichondrin B