Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38

Bioorg Med Chem Lett. 2000 May 15;10(10):1029-32. doi: 10.1016/s0960-894x(00)00150-5.

Abstract

Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Colonic Neoplasms
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Ethers, Cyclic / chemistry*
  • Ethers, Cyclic / pharmacology*
  • Humans
  • Leukemia
  • Macrolides
  • Mice
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Ethers, Cyclic
  • Macrolides
  • halichondrin B