Abstract
A new bisdesmosidic spirostanol saponin, along with three known saponins, were isolated from Agave americana (Agavaceae). The structure of the new saponin was elucidated as (25R)-3 beta,6 alpha-dihydroxy-5 alpha-spirostan-12-one 3,6-di-O-beta-D-glucopyranoside. Among the isolated saponins, hecogenin tetraglycoside showed cytotoxic activity against HL-60 human promyelocytic leukemia cells with an IC50 value of 4.3 micrograms/mL.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Carbohydrate Sequence
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HL-60 Cells
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Spirostans*
Substances
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Antineoplastic Agents, Phytogenic
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Saponins
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Spirostans
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dihydroxy-spirostan-12-one 3,6-di-O-glucopyranoside