A new steroidal saponin from the leaves of Agave americana

Planta Med. 2000 May;66(4):393-6. doi: 10.1055/s-2000-8546.

Abstract

A new bisdesmosidic spirostanol saponin, along with three known saponins, were isolated from Agave americana (Agavaceae). The structure of the new saponin was elucidated as (25R)-3 beta,6 alpha-dihydroxy-5 alpha-spirostan-12-one 3,6-di-O-beta-D-glucopyranoside. Among the isolated saponins, hecogenin tetraglycoside showed cytotoxic activity against HL-60 human promyelocytic leukemia cells with an IC50 value of 4.3 micrograms/mL.

Publication types

  • Letter

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Carbohydrate Sequence
  • HL-60 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Spirostans*

Substances

  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Spirostans
  • dihydroxy-spirostan-12-one 3,6-di-O-glucopyranoside