The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

B H Toh; J W Sentry; F Alderuccio

doi:10.1016/s0167-5699(00)01653-4

The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

Immunol Today. 2000 Jul;21(7):348-54. doi: 10.1016/s0167-5699(00)01653-4.

Authors

B H Toh¹, J W Sentry, F Alderuccio

Affiliation

¹ Department of Pathology and Immunology, Monash University Medical School, Victoria, Australia. Ban-Hock.Toh@med.monash.edu.au

PMID: 10871877
DOI: 10.1016/s0167-5699(00)01653-4

Abstract

The gastric H+/K+ ATPase is the causative autoantigen recognized by CD4+ T cells that mediate autoimmune gastritis. Pathogenic CD4+ T cells are regulated by CD25+CD4+ T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4+ T cells to and from the target organ and draining lymph node result in tissue damage.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antigen Presentation
Autoimmune Diseases / etiology
Autoimmune Diseases / immunology
CD4-Positive T-Lymphocytes / immunology*
Cytotoxicity, Immunologic
Gastritis / etiology*
Gastritis / immunology*
H(+)-K(+)-Exchanging ATPase / immunology*
Humans

Substances

H(+)-K(+)-Exchanging ATPase