[Heat shock proteins or "stress proteins"]

Rev Med Interne. 2000 May;21(5):421-7. doi: 10.1016/s0248-8663(00)88952-3.
[Article in French]

Abstract

Introduction: Heat shock proteins (HSP) are molecular chaperones which facilitate the biosynthesis and maturation of proteins within cells (protein folding). They promote assembly and disassembly of polypeptides and play a major role in cellular function, not only during the stress response but also at basal state.

Current knowledge and key points: As HSP are immunogenic molecules and can be expressed on cellular membranes, their role in auto-immune and inflammatory diseases, particularly in systemic lupus erythematosus, Behçet's disease and rheumatoid arthritis, has been studied. Cellular immune response of T cells and humoral response with antibodies production against HSP occurring in the course of those diseases have been observed.

Future prospects and projects: Anti-HSP immune response might provide better understanding of the pathogenic mechanisms involved in those diseases. At present it is not known whether HSP can trigger them. Indeed, anti-HSP immunity could be induced by the immunological process or be part of a normal immunoregulatory response.

Publication types

  • English Abstract

MeSH terms

  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / physiopathology*
  • Autoimmunity
  • Behcet Syndrome / immunology
  • Behcet Syndrome / physiopathology*
  • Heat-Shock Proteins / biosynthesis
  • Heat-Shock Proteins / immunology
  • Heat-Shock Proteins / physiology*
  • Humans
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / physiopathology*

Substances

  • Heat-Shock Proteins