This study investigated the moderating effect of social support, hardiness, and the components of the hardiness scale of commitment, challenge, and control on the relationship between stress and depression. Hardiness, its components, and support were significantly correlated with scores on the Beck Depression Inventory (BDI). Hardiness and two components (commitment and control) were significantly correlated with stress. Stress was found to be a significant predictor of depression. Hardiness was shown to moderate the relationship between stress and depression such that high-stress, low-hardiness individuals had higher scores on the BDI than did low-stress, low-hardiness individuals. High-hardiness individuals had similar scores on the BDI regardless of their scores on stress. Support was shown to moderate the relationship between stress and depression such that high-stress, low-support individuals had higher scores on the BDI than did low-stress, low-support individuals. High-support individuals had similar scores on the BDI regardless of their scores on stress. Commitment was shown to moderate the relationship between stress and depression such that high-stress, low-commitment individuals had higher scores on the BDI than did low-stress, low-commitment individuals. High-commitment individuals had similar scores on the BDI regardless of their scores on stress.