Reduction in incidence of severe paracetamol poisoning

Lancet. 2000 Jun 10;355(9220):2047-8. doi: 10.1016/S0140-6736(00)02354-0.

Abstract

We report substantial reductions in the frequency of severe paracetamol hepatotoxicity locally and nationally after legislative limitations on its sale. These reductions were not explained by changes in referral patterns or use of N-acetylcysteine.

Publication types

  • Letter

MeSH terms

  • Acetaminophen / poisoning*
  • Acetylcysteine / administration & dosage
  • Adult
  • Analgesics, Non-Narcotic / poisoning*
  • Chemical and Drug Induced Liver Injury*
  • Female
  • Free Radical Scavengers / administration & dosage
  • Humans
  • Incidence
  • Legislation, Drug*
  • Liver Diseases / therapy
  • Male
  • Poisoning / classification
  • Poisoning / epidemiology
  • Poisoning / prevention & control
  • Severity of Illness Index
  • United Kingdom / epidemiology

Substances

  • Analgesics, Non-Narcotic
  • Free Radical Scavengers
  • Acetaminophen
  • Acetylcysteine