Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

J Med Chem. 2000 Aug 24;43(17):3201-4. doi: 10.1021/jm0002477.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anesthetics / chemical synthesis*
  • Anesthetics / chemistry
  • Anesthetics / metabolism
  • Animals
  • Binding, Competitive
  • Brain / metabolism
  • Crystallography, X-Ray
  • Electrophysiology
  • Homosteroids / chemical synthesis*
  • Homosteroids / chemistry
  • Homosteroids / metabolism
  • In Vitro Techniques
  • Molecular Conformation
  • Oocytes
  • Pregnanes / chemical synthesis*
  • Pregnanes / chemistry
  • Pregnanes / metabolism
  • Rats
  • Receptors, GABA-A / metabolism
  • Receptors, GABA-A / physiology
  • Structure-Activity Relationship
  • Xenopus laevis

Substances

  • Anesthetics
  • Homosteroids
  • Pregnanes
  • Receptors, GABA-A