Abstract
Melanin synthesis has been associated with virulence for the human pathogenic fungus Cryptococcus neoformans. Recent evidence indicates that C. neoformans cells synthesize melanin during infection and that this pigment protects the fungus against immune defense mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cryptococcosis / immunology
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Cryptococcosis / microbiology*
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Cryptococcus neoformans / metabolism
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Cryptococcus neoformans / pathogenicity*
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Humans
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Melanins / metabolism*
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Mice
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Virulence