Abstract
Over the past 25 years, the genetic control of cell size has mainly been addressed in yeast, a single-celled organism. Recent insights from Drosophila have shed light on the signalling pathways responsible for adjusting and maintaining cell size in metazoans. Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size.
MeSH terms
-
Animals
-
Cell Cycle / physiology
-
Cell Size / genetics*
-
Drosophila melanogaster / cytology
-
Drosophila melanogaster / genetics
-
Drosophila melanogaster / growth & development*
-
PTEN Phosphohydrolase
-
Phosphatidylinositol 3-Kinases / metabolism
-
Phosphoric Monoester Hydrolases / metabolism
-
Proto-Oncogene Proteins c-myc / physiology
-
Receptor, Insulin / physiology
-
Signal Transduction
-
Tumor Suppressor Proteins*
Substances
-
Proto-Oncogene Proteins c-myc
-
Tumor Suppressor Proteins
-
Phosphatidylinositol 3-Kinases
-
Receptor, Insulin
-
Phosphoric Monoester Hydrolases
-
PTEN Phosphohydrolase