Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

Neuropharmacology. 2001 Mar;40(3):460-3. doi: 10.1016/s0028-3908(00)00184-2.

Abstract

The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholinergic Fibers / drug effects
  • Cholinergic Fibers / metabolism*
  • Corpus Striatum / cytology
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Glycine / analogs & derivatives
  • Glycine / pharmacology
  • In Vitro Techniques
  • Interneurons / drug effects
  • Interneurons / metabolism*
  • Male
  • Membrane Potentials / drug effects
  • Phenylacetates / pharmacology
  • Rats
  • Rats, Wistar
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / agonists
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / biosynthesis*
  • Resorcinols / pharmacology

Substances

  • 2-chloro-5-hydroxyphenylglycine
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Grm5 protein, rat
  • Phenylacetates
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • Resorcinols
  • metabotropic glutamate receptor type 1
  • 3,5-dihydroxyphenylglycine
  • Glycine