Abstract
Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, Pouysségur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription factor kinase, JNK3.
MeSH terms
-
Animals
-
Arrestins / metabolism*
-
Cell Nucleus / metabolism
-
Cells, Cultured
-
Cytosol / metabolism
-
Endosomes / metabolism
-
Enzyme Activation
-
JNK Mitogen-Activated Protein Kinases
-
MAP Kinase Kinase 7
-
MAP Kinase Kinase Kinase 5
-
MAP Kinase Kinase Kinases / metabolism
-
MAP Kinase Signaling System*
-
Mitogen-Activated Protein Kinase 1 / metabolism
-
Mitogen-Activated Protein Kinase 10
-
Mitogen-Activated Protein Kinase Kinases / metabolism
-
Mitogen-Activated Protein Kinases / metabolism*
-
Models, Biological
-
Protein-Tyrosine Kinases / metabolism*
-
Proto-Oncogene Proteins c-jun / metabolism
-
Receptor, Angiotensin, Type 1
-
Receptor, PAR-2
-
Receptors, Angiotensin / metabolism
-
Receptors, Thrombin / metabolism
-
beta-Arrestins
Substances
-
Arrestins
-
Proto-Oncogene Proteins c-jun
-
Receptor, Angiotensin, Type 1
-
Receptor, PAR-2
-
Receptors, Angiotensin
-
Receptors, Thrombin
-
beta-Arrestins
-
Mitogen-Activated Protein Kinase 10
-
Protein-Tyrosine Kinases
-
JNK Mitogen-Activated Protein Kinases
-
Mitogen-Activated Protein Kinase 1
-
Mitogen-Activated Protein Kinases
-
MAP Kinase Kinase Kinase 5
-
MAP Kinase Kinase Kinases
-
MAP Kinase Kinase 7
-
Mitogen-Activated Protein Kinase Kinases