Signal transduction. An arresting start for MAPK

Science. 2000 Nov 24;290(5496):1515-8. doi: 10.1126/science.290.5496.1515.

Abstract

Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, Pouysségur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription factor kinase, JNK3.

Publication types

  • Comment

MeSH terms

  • Animals
  • Arrestins / metabolism*
  • Cell Nucleus / metabolism
  • Cells, Cultured
  • Cytosol / metabolism
  • Endosomes / metabolism
  • Enzyme Activation
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 7
  • MAP Kinase Kinase Kinase 5
  • MAP Kinase Kinase Kinases / metabolism
  • MAP Kinase Signaling System*
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinase 10
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Mitogen-Activated Protein Kinases / metabolism*
  • Models, Biological
  • Protein-Tyrosine Kinases / metabolism*
  • Proto-Oncogene Proteins c-jun / metabolism
  • Receptor, Angiotensin, Type 1
  • Receptor, PAR-2
  • Receptors, Angiotensin / metabolism
  • Receptors, Thrombin / metabolism
  • beta-Arrestins

Substances

  • Arrestins
  • Proto-Oncogene Proteins c-jun
  • Receptor, Angiotensin, Type 1
  • Receptor, PAR-2
  • Receptors, Angiotensin
  • Receptors, Thrombin
  • beta-Arrestins
  • Mitogen-Activated Protein Kinase 10
  • Protein-Tyrosine Kinases
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase Kinase 5
  • MAP Kinase Kinase Kinases
  • MAP Kinase Kinase 7
  • Mitogen-Activated Protein Kinase Kinases