Abstract
A 57-year-old man with nodular rheumatoid arthritis was started on a combination of etanercept and methotrexate. After treatment for five months on this therapy, he presented with new-onset atrial fibrillation. While this report is anecdotal, any new drug warrants intense monitoring for unexpected toxicities in the post-marketing period. Etanercept is being tried in patients with congestive heart failure, where TNF-a seems to be increased. Further surveillance and caution are suggested in patients with known coronary artery disease or atrial dysrhythmia.
MeSH terms
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Antirheumatic Agents / adverse effects*
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Antirheumatic Agents / therapeutic use
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Arthritis, Rheumatoid / drug therapy
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Atrial Fibrillation / chemically induced*
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Atrial Fibrillation / diagnosis
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Atrial Fibrillation / drug therapy
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Drug Therapy, Combination
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Etanercept
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Follow-Up Studies
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Humans
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Immunoglobulin G / adverse effects*
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Immunoglobulin G / therapeutic use
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Male
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Methotrexate / adverse effects*
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Methotrexate / therapeutic use
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Metoprolol / therapeutic use
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Middle Aged
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Receptors, Tumor Necrosis Factor / therapeutic use
Substances
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Antirheumatic Agents
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Immunoglobulin G
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Receptors, Tumor Necrosis Factor
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Metoprolol
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Etanercept
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Methotrexate