Abstract
Members of the AP-1 transcription factor family, especially c-Jun and c-Fos, have long been known to mediate critical steps in the cellular response to ultraviolet (UV) irradiation. We sought to examine whether two newly discovered members of the AP-1 family, JDP-1 and JDP-2, also participate in the mammalian UV response. Here we report that JDP-2, but not JDP-1, is transiently induced upon UV challenge and that elevated levels of JDP-2 increase cell survival following UV exposure. This protective function of JDP-2 appears to be mediated through repression of p53 expression at the transcriptional level, via a conserved atypical AP-1 site in the p53 promoter.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
3T3 Cells
-
Animals
-
Apoptosis / radiation effects*
-
Cell Line
-
Down-Regulation*
-
Fibroblasts / cytology
-
Fibroblasts / metabolism
-
Fibroblasts / radiation effects
-
Gene Expression
-
Mice
-
Promoter Regions, Genetic
-
Proto-Oncogene Proteins c-fos / genetics
-
Proto-Oncogene Proteins c-fos / metabolism
-
Proto-Oncogene Proteins c-jun / genetics
-
Proto-Oncogene Proteins c-jun / metabolism
-
Repressor Proteins / genetics
-
Repressor Proteins / metabolism
-
Repressor Proteins / physiology*
-
Transcription Factor AP-1
-
Transcriptional Activation / radiation effects
-
Tumor Suppressor Protein p53 / genetics*
-
Ultraviolet Rays
Substances
-
Jundp2 protein, mouse
-
Proto-Oncogene Proteins c-fos
-
Proto-Oncogene Proteins c-jun
-
Repressor Proteins
-
Transcription Factor AP-1
-
Tumor Suppressor Protein p53