Abstract
Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters*
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Alleles
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Animals
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Antimalarials / pharmacology
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Antimalarials / therapeutic use*
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Chloroquine / pharmacology
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Chloroquine / therapeutic use*
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Clone Cells
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Drug Resistance
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Genes, Protozoan
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Humans
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Linkage Disequilibrium
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / parasitology
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Membrane Proteins / genetics*
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Membrane Transport Proteins
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Mutation
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / genetics
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Plasmodium falciparum / isolation & purification
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Polymorphism, Genetic
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Protozoan Proteins / genetics*
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Sudan
Substances
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ATP-Binding Cassette Transporters
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Antimalarials
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Membrane Proteins
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Membrane Transport Proteins
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PfCRT protein, Plasmodium falciparum
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Protozoan Proteins
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mdr gene protein, Plasmodium
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Chloroquine