Neuronal differentiation: proneural genes inhibit gliogenesis

S J Morrison

doi:10.1016/s0960-9822(01)00191-9

Neuronal differentiation: proneural genes inhibit gliogenesis

Curr Biol. 2001 May 1;11(9):R349-51. doi: 10.1016/s0960-9822(01)00191-9.

Author

S J Morrison¹

Affiliation

¹ Howard Hughes Medical Institute, Departments of Internal Medicine and Cell and Developmental Biology, 3215 CCGC, University of Michigan, Ann Arbor, Michigan 48109-0934, USA.

PMID: 11369245
DOI: 10.1016/s0960-9822(01)00191-9

Abstract

Proneural basic helix-loop-helix transcription factors such as Neurogenin are activators of neuronal gene expression. Recent studies show they reinforce neuronal differentiation by also inhibiting the expression of glial genes, and are required in vivo to prevent premature and excessive gliogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / genetics*
DNA-Binding Proteins / physiology
Gene Expression Regulation / physiology
Helix-Loop-Helix Motifs
Neuroglia / cytology*
Neurons / cytology*
Transcription Factors / physiology

Substances

DNA-Binding Proteins
Transcription Factors