Abstract
Phenylcyclohexenes (PCHs) [e.g., trans-4-nitro-5-(2,3,4-trimethoxyphenyl)cyclohexene, 2d] were found to bind weakly to the colchicine site of bovine tubulin, but are the first mimics of colchicine found to have high activity towards plant cells. Structure-activity relationships for PCHs and biphenyl AC-ring analogues of colchicine (e.g., 2,3,4,4'-tetramethoxy-2'-methyl-1,1'-biphenyl, 3e) are discussed.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Colchicine / chemistry
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Cyclohexanes / chemistry
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Cyclohexanes / pharmacology*
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Cyclohexenes
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Herbicides / chemistry
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Herbicides / pharmacology*
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Nicotiana
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Nitro Compounds / chemistry
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Nitro Compounds / pharmacology*
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Plant Roots / cytology
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Plant Roots / drug effects
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Plants, Toxic
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Structure-Activity Relationship
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Tubulin / metabolism
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Tubulin Modulators*
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Tumor Cells, Cultured
Substances
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4-nitro-5-(2,3,4-trimethoxyphenyl)cyclohexene
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Antineoplastic Agents
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Cyclohexanes
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Cyclohexenes
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Herbicides
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Nitro Compounds
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Tubulin
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Tubulin Modulators
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1-phenylcyclohex-1-ene
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Colchicine