The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation

FASEB J. 2001 Jun;15(8):1416-8. doi: 10.1096/fj.00-0678fje.

Authors

I Simonitsch¹, D Polgar, M Hajek, P Duchek, B Skrzypek, S Fassl, A Lamprecht, G Schmidt, G Krupitza, C Cerni

Affiliation

¹ Institute of Clinical Pathology, Institute of Cancer Research, University of Vienna, A-1090 Vienna, Austria.

PMID: 11387242
DOI: 10.1096/fj.00-0678fje

No abstract available

MeSH terms

Anaplastic Lymphoma Kinase
Animals
Cell Division
Cell Transformation, Neoplastic / genetics*
Genes, ras
Lymphoma, Large-Cell, Anaplastic / genetics
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Nucleophosmin
Peptide Fragments
Protein-Tyrosine Kinases / genetics*
Rats
Receptor Protein-Tyrosine Kinases / genetics*
Receptor Protein-Tyrosine Kinases / metabolism
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / metabolism
Repressor Proteins / genetics
Repressor Proteins / metabolism

Substances

Nuclear Proteins
Peptide Fragments
Recombinant Fusion Proteins
Repressor Proteins
tetracycline resistance-encoding transposon repressor protein
Nucleophosmin
Alk protein, rat
Anaplastic Lymphoma Kinase
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases