Abstract
A prospective, randomized clinical trial among drug abusers was conducted to assess the efficacy and safety of a short course of a combination of a glycopeptide (vancomycin or teicoplanin) and gentamicin compared with a combination of cloxacillin and gentamicin for treatment of right-side endocarditis caused by Staphylococcus aureus. Therapeutic success was significantly more frequent with cloxacillin than with a glycopeptide. No adverse effects were noted among patients in the cloxacillin group. A 14-day course of vancomycin or teicoplanin plus gentamicin is ineffective in this instance because it is associated with a high rate of clinical and microbiological failure.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / therapeutic use
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Cloxacillin / therapeutic use
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Drug Therapy, Combination / therapeutic use*
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Endocarditis, Bacterial / complications
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Female
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Gentamicins / therapeutic use
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Glycopeptides
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Humans
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Male
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Prospective Studies
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Staphylococcal Infections / complications
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus*
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Substance Abuse, Intravenous / complications*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Gentamicins
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Glycopeptides
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Cloxacillin