Objective: To examine the effects of creatine supplementation on anterior compartment pressure of the lower leg at rest and following exercise.
Design: 14 college-age males received creatine or placebo supplementation for 34 days. At baseline, anterior compartment pressure was measured preexercise, immediately postexercise, and 1, 5, and 15 minutes postexercise after a level treadmill run for 20 minutes at 80% of maximal aerobic power.
Intervention: Following baseline testing, subjects began a 6-day creatine or placebo loading phase at a dosage of 0.3 g x kg body mass(-1) x d(-1). This was followed by a 28-day maintenance phase at a dosage of 0.03 g x kg body mass(-1) x d(-1). Subjects and investigators were blinded as to treatment administration. Subjects continued to exercise during the supplementation period. After 6 days and 34 days of supplementation. anterior compartment pressure was measured at rest and following exercise.
Results: Creatine supplementation for 6 days significantly increased compartment pressure compared with the placebo group at rest (76%), immediately post- (150%), 1 minute post- (125%), 5 minute post- (106%), and 15 minute postexercise (77%). Anterior compartment pressures continued to remain significantly higher for the creatine group compared with the placebo group at rest (72%), immediately post- (125%) and 1 minute postexercise (180%) after 34 days of creatine supplementation.
Conclusions: These data indicate that creatine supplementation abnormally increases anterior compartment pressure in the lower leg at rest and following 20 minutes of level running at 80% of maximal aerobic power.