Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

Nat Genet. 2001 Jul;28(3):220-1. doi: 10.1038/90054.

Abstract

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 1 / genetics
  • Chromosomes, Human, Pair 22 / genetics
  • DNA-Binding Proteins / genetics*
  • Humans
  • Leukemia, Megakaryoblastic, Acute / genetics*
  • Molecular Sequence Data
  • Oncogene Proteins, Fusion / genetics*
  • RNA-Binding Proteins / genetics*
  • Trans-Activators
  • Translocation, Genetic*

Substances

  • DNA-Binding Proteins
  • MRTFA protein, human
  • Oncogene Proteins, Fusion
  • RBM15 protein, human
  • RNA-Binding Proteins
  • Trans-Activators

Associated data

  • GENBANK/AB037859
  • GENBANK/AF145664
  • GENBANK/AF364035
  • GENBANK/AF364036
  • GENBANK/AF364037
  • GENBANK/AF368061
  • GENBANK/AF368062
  • GENBANK/AF368063
  • GENBANK/AF368064
  • GENBANK/AK022541
  • GENBANK/AK025596