Abstract
1. The study evaluated the efficacy of amisulpride, fluoxetine and clomipramine at the beginning of the re-feeding phase of the treatment of restricting anorexia nervosa according to DSM-IV criteria. 2. 13 patients, mean weight 37.61 kg +/- 9.80 SD, were treated with clomipramine at a mean dosage of 57.69 mg +/- 25.79 SD; 10 patients, mean weight 40.90 kg +/- 6.98 SD, were treated with fluoxetine at a mean dosage of 28.00 mg +/- 10.32 SD; 12 patients, mean weight 38.41 kg +/- 8.33 SD, were treated with amisulpride at a mean dosage of 50.00 mg +/- 0.00 SD. 3. Clinical evaluation was carried out under single-blind condition at basal time and after three months by a structured clinical interview, the Eating Disorder Interview based on Long Interval Follow-up Evaluation (LIFE II BEI). 4. Patients treated with amisulpride showed a more significant increase (p=0.016) of mean weight. Concerning weight phobia, body image disturbance and amenorrhoea, no significant difference resulted.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adult
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Amenorrhea / etiology
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Amisulpride
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Anorexia Nervosa / drug therapy*
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Anorexia Nervosa / psychology
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Antidepressive Agents, Second-Generation / administration & dosage
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Antidepressive Agents, Second-Generation / pharmacology*
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Antidepressive Agents, Tricyclic / administration & dosage
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Antidepressive Agents, Tricyclic / pharmacology*
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Antipsychotic Agents / administration & dosage
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Antipsychotic Agents / pharmacology*
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Body Image
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Clomipramine / administration & dosage
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Clomipramine / pharmacology*
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Diet Therapy
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Drug Therapy, Combination
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Female
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Fluoxetine / administration & dosage
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Fluoxetine / pharmacology*
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Humans
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Male
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Single-Blind Method
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Sulpiride / administration & dosage
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Sulpiride / analogs & derivatives*
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Sulpiride / pharmacology*
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Treatment Outcome
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Weight Gain
Substances
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Antidepressive Agents, Second-Generation
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Antidepressive Agents, Tricyclic
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Antipsychotic Agents
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Fluoxetine
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Sulpiride
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Amisulpride
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Clomipramine