A 9 year study of clarithromycin and metronidazole resistance in Helicobacter pylori from Spanish children

J Antimicrob Chemother. 2001 Aug;48(2):295-7. doi: 10.1093/jac/48.2.295.

Abstract

The evolution of clarithromycin, metronidazole and amoxycillin resistance in 246 Spanish Helicobacter pylori clinical isolates, obtained from paediatric patients during a 9 year period, was determined by an agar dilution technique. Clarithromycin resistance (MIC 1 mg/L) was 2.27% (IC95 0.05-12.02) in 1991-1993, 20.98% (IC95 12.72-31.46) in 1994-1996 and 28.33% (IC95 20.48-37.28) in 1997-1999 (P < 0.01). Metronidazole resistance (MIC 8 mg/L) was 7.14% (IC95 1.49-19.48) in 1991-1993, 20.25% (IC95 12.04-30.79) in 1994-1996 and 43.90% (IC95 32.95-55.30) in 1997-1999 (P < 0.01). Amoxycillin resistance was not found (all strains showed MICs < 2 mg/L).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Clarithromycin / pharmacology*
  • Clarithromycin / therapeutic use
  • Confidence Intervals
  • Drug Resistance, Bacterial*
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / isolation & purification
  • Humans
  • Metronidazole / pharmacology*
  • Metronidazole / therapeutic use
  • Microbial Sensitivity Tests
  • Spain

Substances

  • Anti-Bacterial Agents
  • Metronidazole
  • Clarithromycin