Abstract
Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.). A dose-dependent inhibition of the antinociception induced by arecoline was observed after inactivation of the M1 gene by an antisense oligodeoxyribonucleotide (aODN). This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors.
MeSH terms
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Analgesics, Non-Narcotic / pharmacology*
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Animals
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Arecoline / pharmacology*
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Injections, Intraperitoneal
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Injections, Intraventricular
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Male
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Mice
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Muscarinic Agonists / pharmacology*
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Muscarinic Antagonists / pharmacology
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Oligonucleotides, Antisense / pharmacology
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Phenylacetates / pharmacology
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Piperidines / pharmacology
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Pirenzepine / pharmacology
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Rats
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Reaction Time / drug effects
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Receptor, Muscarinic M1
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Receptors, Muscarinic / drug effects*
Substances
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Analgesics, Non-Narcotic
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ET 126
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Muscarinic Agonists
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Muscarinic Antagonists
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Oligonucleotides, Antisense
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Phenylacetates
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Piperidines
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Receptor, Muscarinic M1
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Receptors, Muscarinic
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Pirenzepine
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Arecoline